for openVZ guests there is no problem. only some windows KVM´s can complain about new hardware and needs reboot, depending on you licensing it could be necessary to reactivate the windows because of some "hardware" changes.
I move some production system from 2.6.24 to 2.6.18 without any issues. just remember the hint from Udo regarding the missing scsi on 2.6.18 for KVM guests.