you mean remove all services from being HA managed in a single step?
The web UI/API and CLI only allows for removing a service at once, but if you want to remove all you can simply remove the whole config where it's defined which service should be managed by HA, e.g.:
Bash:
rm /etc/pve/ha/resources.cfg
Note that it might need a few minutes until that went through to all notes, and the run-status of the VMs & CTs themselves should not be affected by this.
I don't know anything about your setup so cannot give a definitive answer, but as removing services from being managed by the HA stack isn't inherently risky, doing so en masse isn't really either.