The zpool upgrade should not be an issue then - but as always before touching the disk-configuration of a productive system - make sure you have working and tested backups!So, what you are saying is, if zfs is not used for boot, everything will be fine and zpool upgrade should work fine?
I have the zpool on 2 partitions outside of booting areas (nvme0n1p3/nvme1n1p3):
For completeness sake - mdraid is not supported by us.