Proxmox does not support making a backup of just a virtual disk. You can make backups of the whole VM ignore a virtual disk by unticking the Backup option of the virtual disk (click Edit after selecting the Hard Disk of the VM). Be aware that a restore of the VM backup will first delete all virtual disks and then only restore the virtual disk that was backed up.
If you can do without TrueNAS you could also let the node itself manage the ZFS pool and then provide shares via a CT or VM which you can give a virtual drive from that pool/storage.