I also have the same concerns, I have very limited space, in my set up I have a bunch of usb ports, only one PCIe 4.0 slot and 4 3.5" bays. I'm planning on using the 4 bays just for data storage. In that case, I most likely need to run Proxmox from USB. I had a bunch of M.2 SSD lying around and went ahead and bought an enclosure for one to install Proxmox on it. but I hear a lot of chatter about issues with IOPS if I take that route. I'd appreciate some help in finalizing this set up.
Also some additional questions, I probably have to use the PCIe interface to put in an NVMe drive in there for VMs. The system doesn't support bifurcation, how bad would it be if I put Proxmox on m.2 SSD and run it from the USB port, put the VMs on the NVMe drive and not have any mirrors for either of the dives? And what are the limitations with this set up?
p.s.: I can possibly get a NVMe PCIe adapter with a chip and put 2 NVMe drives on it and mirror the VM drive, but still no way of mirroring the boot drive.