That is the beauty of ZFS
Again, I am not sure what your config is, what your VM(s) are, what is in them and so on.
Seems like we have to worm everything out of you. But ZFS doesn't come for free.
As far as I understand it, you have one single 14TB Windows VM that you move from VMware to Proxmox.
I don't know why you would call that a backup, but ok.
So you now decided to go with 64k, which is perfect for your pool geometry when it comes to storage efficiency!
But every write that is smaller than 64k you will suffer from io amplification and fragmentation.
Since you are already at 80% full, your node is already on the edge. If you only get slightly more data or fragmentation, performance will absolutely tank.