Yes, using discard in /etc/fstab or fstrim in crontab is working fine on rbd to release space.
(just enable discard too on the vm disk option).
Just be carefull of discard in /etc/fstab, before kernel 4.7, it was not async, so you need to wait when you delete a file.
with kernel >= 4.7, it's async, so no performance degradation.