Proxmox VMs freezing up with high IO delay at exactly the same time every day for exactly 5 mins

Mixed drives = worst drive wins → ZFS RAIDZ is slowed down to the slowest SSD (the Blue).

Consumer SSDs (Blue) are not made for VMs → low endurance, unstable latency, no power-loss protection.

RAIDZ is already bad for VM I/O → combine that with mixed SSDs = slow, inconsistent, high risk of failure.

Go for enterprise SSDs. As mentioned before by @_gabriel : create a striped mirror. This will give you much better performance.
 
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