Just spend some hours hunting down ghosts, and wanted to help anyone having the same issue as me:
I created a NFS share on a Synology NAS, mounted it to the PVE and run a backup. All fine so far. After some days it dropped offline. For good.
I did all the tests,
ping works,
nmap as well:
but
So the solution for this beauty is to disable in the Synology NAS under networking "Reply to ARP requests if the target IP address is a local address configured on the incoming interface"

Luckily I found this tread, just created a streamlined version since it took me almost two hours for finding it - maybe you are quicker
https://forum.proxmox.com/threads/mount-no-longer-works-in-proxmox-6-nfs-synology.56503/post-263048
I created a NFS share on a Synology NAS, mounted it to the PVE and run a backup. All fine so far. After some days it dropped offline. For good.
I did all the tests,
ping works,
nmap as well:
user@host:~# nmap -p 111,2049 10.0.0.1
Starting Nmap 7.93 ( https://nmap.org ) at 2025-05-17 23:34 CEST
Nmap scan report for 10.0.0.1
Host is up (0.00057s latency).
PORT STATE SERVICE
111/tcp open rpcbind
2049/tcp open nfs
MAC Address: 90:091:44:33:8C (Synology Incorporated)
Nmap done: 1 IP address (1 host up) scanned in 0.11 seconds
but
user@host:~#showmount -e 10.0.0.1
rpc mount export: RPC: Unable to receive; errno = No route to host
So the solution for this beauty is to disable in the Synology NAS under networking "Reply to ARP requests if the target IP address is a local address configured on the incoming interface"

Luckily I found this tread, just created a streamlined version since it took me almost two hours for finding it - maybe you are quicker

https://forum.proxmox.com/threads/mount-no-longer-works-in-proxmox-6-nfs-synology.56503/post-263048