in general this is not possible.
the details depend on whether or not you have 'before queue filtering' enabled:
* if it is enabled (and all recipients blocked) the mail - the sender should have gotten a bounce from their mailsystem - and can resend it
* if not (and you don't have NDR on blocked emails enabled) - the sender got a 250 OK back and is unaware of the problem.
I hope this explains it