I have a Windows guest with both igpu and usb controller passthrough. The other day I did a whole system upgrade including upgrading kernel from 5.13.19-6-pve to 5.15.35-1-pve.
After the upgrade, my system became like,
# pveversion
pve-manager/7.2-4/ca9d43cc (running kernel: 5.15.35-1-pve)...