Sure.
I dont use openvswitch.
auto lo
iface lo inet loopback
iface lo inet6 loopback
auto enp4s0
iface enp4s0 inet static
address [HostIP]
netmask 255.255.255.224
gateway [Gateway]
pointopoint [Gateway]
up route add -net 78.46.X.X netmask 255.255.255.224 gw [Gateway]...