Running PVE on hosts with 512/512 disks, storage is ZFS (ashift=12) and Ceph.
Guests use virtio-scsi-single, mostly Linux, some Windows.
I wonder if it's worth adding (or similiar):
args: -global scsi-hd.physical_block_size=4096 -global scsi-hd.logical_block_size=4096
For Linux it feels...