Ok thx man ! That was not the issue but you helped me (sort off).
The issue was some default setting in teh bios.
When updating the bios the SATA/NVMe is set to "Raid ON" in stead of AHCI/NVMe.
See picture.
Now the systems are working again ...
one year lataer and proble is still there even any change in auto suspend, happend with any USB Wireless network device. https://bugzilla.proxmox.com/show_bug.cgi?id=6880