Like with any deployment, start with a proof-of-concept testbed.
As you know, separate OS from data. So, use small drives to mirror the OS. I use ZFS RAID-1. Rest of bigger drives for VMs/data. Strongly suggest to use a IT/HBA-mode storage...
Just get a used Dell HBA330 storage controller. Flash latest firmware and Proxmox will use the simpler mpt3sas driver.
I run it in production with both ZFS and Ceph with no issues.
Best practice is to separate OS and data storage.
So, install OS on small boot drives mirrored. I use ZFS RAID-1. Then rest of drives for VMs/data.
Your future self will thank you.