Well now I fixed this by renaming the jaraco folder /usr/lib/python3/dist-packages/jaraco to jaraco-old
Now it works
Seems like that got installed with ceph and broke the ifup program, as if it exists then it will try to use it
If it doesn't...
Holy Debian god, this was the fix for my issues as well, wow.
Had forced reboot and after that no network, renaming that folder and reboot after no issues. Lesson learned to never ignore clear errors like this, spend two evenings with this...