Proxmox (because of Linux) handles hardware changes quite well and you are not moving to the lvery atest generation, so you should not have problems with drivers.
Your new network device will have a different name on a new motherboard and you need to fix that (in /etc/network/interface) or you won't be able to access the Proxmox system (via SSH or web GUI).
Make sure to disable auto-start of all VMs that use PCI(e) passthrough before changing the motherboard, because most PCIe devices will have a different PCI ID. You'll also need to recheck your IOMMU groups before changing the PCIe passthrough accordingly. Hopefully your new motherboard&CPU have good groups and supports IOMMU.